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Dual crosslinked injectable protein-based hydrogels with cell anti-adhesive properties
1Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Odisha 769008, India.
Biomedical Materials (Bristol, England)
|January 30, 2023
Summary
Researchers developed a novel injectable hydrogel from albumin (BSA) using dual crosslinking. This stable and robust material effectively prevents post-surgical tissue adhesions, showing promise for biomedical applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Post-surgical tissue adhesions are a significant clinical challenge.
- Current methods to prevent adhesions often involve films or hydrogels for tissue separation.
Purpose of the Study:
- To develop a novel, stable, robust, and injectable dual crosslinking hydrogel using albumin (BSA).
- To evaluate the hydrogel's potential for preventing post-surgical tissue adhesions.
Main Methods:
- Created a dual crosslinking hydrogel using bovine serum albumin (BSA) with calcium ions (Ca2+) and tetrakis(hydroxymethyl) phosphonium chloride.
- Assessed hydrogel properties including mechanical strength, self-healing, tissue adhesion, cytocompatibility, and gelling time.
Main Results:
- The dual crosslinked hydrogel exhibited preserved microstructure during degradation, enhancing mechanical strength (48.81 kPa at 60% strain) and stability.
- Demonstrated excellent self-healing within 25 minutes, good tissue adhesion, cytocompatibility, and rapid gelling (27 ± 6 s).
Conclusions:
- The developed BSA-based dual crosslinked injectable hydrogel shows significant potential for biomedical applications.
- This hydrogel is a promising candidate for preventing post-surgical tissue adhesions due to its stability, mechanical properties, and biocompatibility.
