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Effect of antipsychotic use by patients with schizophrenia on deceleration capacity and its relation to the corrected

Hiroaki Okayasu1, Takahiro Shinozaki1, Yumiko Takano1

  • 1Department of Psychiatry, Dokkyo Medical University, Tochigi, Japan.

General Hospital Psychiatry
|January 30, 2023
PubMed

Insights

Antipsychotic use in schizophrenia patients is linked to reduced heart rate deceleration capacity (DC), a predictor of cardiac death. Monitoring DC may help identify at-risk patients.

Area of Science:

  • Cardiology
  • Psychiatry
  • Pharmacology

Background:

  • Schizophrenia patients on antipsychotics face increased sudden cardiac death risk.
  • Deceleration capacity (DC) of heart rate predicts cardiac mortality.
  • Antipsychotic medications can affect cardiac function.

Purpose of the Study:

  • To evaluate sudden cardiac death risk in schizophrenia patients treated with antipsychotics.
  • To assess heart rate deceleration capacity (DC) in these patients.
  • To examine the association between DC and corrected QT interval (QTc).

Main Methods:

  • Measured DC and QTc in 138 schizophrenia patients.
  • Compared DC between patients and 86 healthy controls.
  • Analyzed DC correlation with antipsychotic dose and QTc in patients.

Main Results:

  • Schizophrenia patients on antipsychotics showed significantly lower DC than controls.
  • DC negatively correlated with antipsychotic dose (chlorpromazine, zotepine, olanzapine, clozapine).
  • No significant association found between DC and QTc.

Conclusions:

  • Assessing DC can help monitor and identify cardiac mortality risk in schizophrenia patients on antipsychotics.
  • Combined assessment of DC and QTc may improve sudden cardiac death prediction.
Abstract

Keywords:
AntipsychoticsDeceleration capacityHeart rate variabilityQT intervalSchizophreniaSudden cardiac death

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