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Gastroesophageal Reflux Treatment in Infancy Through Young Adulthood

Rachel Rosen1

  • 1Boston Children's Hospital, Center for Motility and Functional Gastrointestinal Disorders, Aerodigestive Center, Boston, Massachusetts, USA.

The American Journal of Gastroenterology
|January 30, 2023
PubMed

Insights

Pediatric gastroesophageal reflux treatment differs by age, using nutrition for infants and medication for older children. Nonresponse necessitates re-evaluation and further testing for a precision medicine approach.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Disorders
  • Pharmacology

Background:

  • Gastroesophageal reflux (GER) management strategies significantly vary across pediatric age groups.
  • Infant GER treatment primarily involves nutritional interventions.
  • Older children with GER are more frequently managed with pharmacotherapy.

Purpose of the Study:

  • To highlight the age-dependent treatment variations in pediatric gastroesophageal reflux.
  • To emphasize the importance of diagnostic re-evaluation in cases of treatment nonresponse.
  • To advocate for a precision medicine approach in managing pediatric GER.

Main Methods:

  • Review of current literature on pediatric gastroesophageal reflux treatment guidelines.
  • Analysis of age-specific therapeutic modalities for GER.
  • Discussion of diagnostic challenges and the role of further investigations.

Main Results:

  • Nutritional interventions are the cornerstone for infant GER.
  • Medications are the predominant treatment for GER in older children.
  • Treatment nonresponse is common due to a broad differential diagnosis.

Conclusions:

  • Pediatric GER treatment requires age-tailored strategies.
  • Persistent GER symptoms despite initial treatment warrant diagnostic reassessment.
  • Implementing precision medicine can optimize GER management in children.

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