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Vessel Rupture Thresholds for Vessel-Bubble Interactions Using an Earthworm Vasculature Model.

Asis Lopez1, Jenna Osborn2, Rachael Irwin3

  • 1Bioinnovation Ph.D. Program, Biomedical Engineering Department, Tulane University, New Orleans, LA, USA; U.S. Food and Drug Administration, Silver Spring, MD, USA.

Ultrasound in Medicine & Biology
|January 30, 2023
PubMed
Summary
This summary is machine-generated.

This study quantified vessel damage from microbubble oscillation during ultrasound therapy using earthworms. A modified mechanical index (MMI) effectively predicted rupture thresholds, aiding safer therapeutic ultrasound development.

Keywords:
Blood vesselBlood–brain barrierCavitationContrast agentEarthwormMechanical indexMicrobubblesMicrovesselsTherapeutic ultrasoundVascular bio-effectsVessel rupture mechanism

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Area of Science:

  • Biomedical Engineering
  • Acoustic Cavitation
  • Vascular Mechanics

Background:

  • Therapeutic ultrasound with microbubbles offers benefits but risks vessel damage.
  • Quantifying mechanical effects of microbubble oscillation is crucial for safety.
  • Earthworm vasculature serves as a suitable model due to elastic properties similar to human arteries.

Purpose of the Study:

  • To investigate the mechanical effects of microbubble oscillation on blood vessels under ultrasound.
  • To quantify vessel rupture probability and time as a function of ultrasound parameters.
  • To develop a predictive model for vascular safety in microbubble-based therapies.

Main Methods:

  • Infusing microbubbles into earthworm vasculature.
  • Sonicating vessels at varying ultrasound frequencies, pulse repetition frequencies, and acoustic pressures.
  • Recording microbubble rupture time and correlating it with ultrasound parameters.

Main Results:

  • A modified mechanical index (MMI) was developed to correlate with microbubble rupture probability and time.
  • A database of vessel rupture thresholds was established.
  • A potential radiation-force effect was observed in the absence of bubbles.

Conclusions:

  • The MMI effectively correlates with vessel rupture in the presence of microbubbles.
  • Further research is needed to elucidate the mathematical dependence of MMI on rupture.
  • Findings will inform future studies in vertebrate models and computational simulations for safer ultrasound therapies.