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Resting-state network functional connectivity before and after bariatric surgery.

Kailey Langer1, Keyanni Joy Johnson1, John B Williamson1

  • 1Center for Cognitive Aging and Memory, University of Florida, Gainesville, Florida.

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
|January 30, 2023
PubMed
Summary
This summary is machine-generated.

Bariatric surgery may improve brain connectivity in obese patients. Lower baseline resting-state functional connectivity (RSFC) predicts greater improvement, suggesting RSFC as a neurocognitive biomarker. Obesity-related conditions like type 2 diabetes negatively impact RSFC.

Keywords:
Bariatric surgeryBrain functionInflammationNeuroimagingObesity

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Metabolic Disorders

Background:

  • Bariatric surgery is a common treatment for severe obesity and associated conditions like diabetes and cardiovascular disease.
  • Obesity and bariatric surgery are linked to altered brain functional connectivity.
  • Understanding these brain changes is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate brain function using resting-state within-network connectivity in patients undergoing bariatric surgery for severe obesity.
  • To identify predictors of baseline and changes in resting-state functional connectivity (RSFC).

Main Methods:

  • Functional neuroimaging (resting-state functional connectivity) was performed on 34 bariatric surgery patients at baseline and approximately 16 weeks postoperatively.
  • Patient data included age, body mass index (BMI), CPAP use, and history of rheumatoid arthritis and type 2 diabetes.
  • Statistical models predicted baseline RSFC and change in RSFC, with and without controlling for baseline connectivity.

Main Results:

  • Higher baseline BMI was associated with lower baseline RSFC in three networks.
  • Rheumatoid arthritis and type 2 diabetes were also linked to lower baseline RSFC.
  • Lower baseline RSFC predicted a greater positive change in connectivity post-surgery, especially when controlling for baseline RSFC and type 2 diabetes.

Conclusions:

  • Resting-state functional connectivity (RSFC) may indicate brain dysfunction in obesity and related diseases.
  • Reduced baseline RSFC predicts greater neurocognitive improvement after bariatric surgery, suggesting its potential as a biomarker.
  • Inflammatory pathways associated with obesity, type 2 diabetes, and rheumatoid arthritis likely contribute to negative effects on RSFC.