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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

31
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

49
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
49
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

54
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
54
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

39
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
39

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Kidney Bioengineering for Transplantation.

Yutaro Ibi1, Ryuichi Nishinakamura

  • 1Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

Transplantation
|January 31, 2023
PubMed
Summary
This summary is machine-generated.

Generating transplantable kidneys is crucial due to donor shortages. Researchers are exploring bioengineering strategies, including stem cell-derived kidney organoids and other advanced methods, to create viable organs for transplantation.

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Area of Science:

  • Regenerative Medicine
  • Bioengineering
  • Stem Cell Biology

Background:

  • Kidney failure necessitates renal replacement therapy, but donor organs are scarce.
  • Human induced pluripotent stem cells (hiPSCs) offer a promising source for generating kidney cells.
  • Kidney organoids derived from hiPSCs are valuable for studying kidney development and disease.

Purpose of the Study:

  • To investigate strategies for generating transplantable bioengineered kidneys.
  • To explore the potential of combining different renal progenitor sources for kidney organoid generation.
  • To review various bioengineering approaches for whole kidney generation.

Main Methods:

  • Induction of nephron progenitors from hiPSCs.
  • Generation of kidney organoids through progenitor combination.
  • Review of bioengineering strategies: decellularization/recellularization, 3D bioprinting, blastocyst complementation, progenitor replacement, and xenotransplantation.

Main Results:

  • hiPSC-derived kidney organoids show potential for studying kidney development and disease.
  • Combining multiple renal progenitors is a key strategy for advanced organoid development.
  • Various bioengineering techniques hold promise for creating whole kidneys, each with unique challenges.

Conclusions:

  • Combining multiple bioengineering strategies is likely necessary for generating transplantable human kidneys.
  • Advancements in stem cell technology and bioengineering are paving the way for future kidney therapies.
  • Addressing the donor organ shortage through bioengineered kidneys is a critical goal in transplantation medicine.