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Immunopotentiating activity of a nucleotide derivative, heptaminol AMP amidate (HAA) in mice and spontaneously
A R Saha1, K Ueno, H Mitsuhashi
1Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Abstract:
The immunopotentiating activity of heptaminol AMP amidate (HAA), a new derivative of 5'-AMP, was examined in experimental animals. Anti-SRBC PFC activity and antibody titer values augmented for both of single and 4 days consecutive administrations in ICR male mice. The dose of 10 mg/kg was found to cause the maximum enhancement. In spontaneously hypertensive rats, with a state of immunosuppression, 10 days consecutive administrations of HAA at the dose of 10 mg/kg was found to increase significantly the anti-SRBC PFC and antibody titer values. From these results, it is tempting to suggest that HAA may possess an immunopotentiating activity.