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Evaluation of botulinum toxin type A for treating post burn hypertrophic scars and keloid in children: An

Abeer Attia Tawfik1, Rama Ahmad Ali2

  • 1Nationonal Institute of Laser Enhanced Sciences Cairo University, Cairo University, Giza, Egypt.

Journal of Cosmetic Dermatology
|January 31, 2023
PubMed

Insights

Botulinum toxin injections effectively treat hypertrophic scars and keloids in children, improving scar appearance and reducing symptoms like itching and pain. This study confirms its safety and efficacy for pediatric scar management.

Area of Science:

  • Dermatology
  • Pediatric Surgery
  • Wound Healing

Background:

  • Management of pediatric hypertrophic scars and keloids presents significant challenges for clinicians, families, and patients.
  • Effective and safe treatment options for these scar types in children are limited.

Purpose of the Study:

  • To evaluate the efficacy and safety of botulinum toxin injections for treating hypertrophic and keloid scars in pediatric patients.
  • To compare the outcomes of botulinum toxin treatment against a control in a randomized intra-patient study.

Main Methods:

  • A randomized intra-patient comparative study involving 15 children with post-burn hypertrophic or keloid scars.
  • One scar portion received Intralesional botulinum toxin injections, while the other served as a control.
  • Clinical improvement was assessed using the Vancouver Scar Scale (VSS) and a skin analysis camera system over six monthly sessions.

Main Results:

  • Significant clinical and statistical improvements were observed in vascularity, pliability, and height in the botulinum toxin-treated areas.
  • Skin analysis confirmed marked changes in scar vascularity and height post-treatment.
  • No correlation was found between Vancouver score improvement and patient/lesion characteristics like age, sex, skin type, or scar duration/type.

Conclusions:

  • Botulinum toxin injections demonstrate efficacy and safety in treating pediatric hypertrophic scars and keloids.
  • Treatment led to improvements in scar pliability, erythema, and thickness.
  • Botulinum toxin also effectively alleviated associated symptoms of itching and pain in pediatric patients.
Abstract

Keywords:
botulinum toxinhypertrophic scarskeloid

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