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Twin Anemia-Polycythemia Sequence (TAPS): From Basic Research to Clinical Practice
Joana da Silva Rocha1, Luís Guedes-Martins1,2,3,4, Ana Cunha2,3
1Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto 4050-313, Portugal.
Current Vascular Pharmacology
|January 31, 2023
Summary
Twin Anemia-Polycythemia Sequence (TAPS) involves vascular connections in monochorionic twins. Early recognition and understanding of TAPS pathophysiology are crucial for managing twin pregnancy complications.
Area of Science:
- Perinatology
- Maternal-Fetal Medicine
- Vascular Biology
Background:
- Monochorionic (MC) twin pregnancies carry higher risks for perinatal and maternal complications.
- The type of chorionicity and placental vascular anastomoses significantly influence pregnancy outcomes.
- Twin Anemia-Polycythemia Sequence (TAPS) is an increasingly recognized fetofetal transfusion syndrome in MC twins.
Approach:
- This review synthesizes current literature on TAPS epidemiology, pathophysiology, and hemodynamics.
- It examines the evolution of antenatal and postnatal diagnostic criteria for TAPS.
- The review discusses proposed secondary markers and ongoing debates regarding optimal screening protocols.
Key Points:
- TAPS involves specific vascular anastomoses (small AV, low-rate AA) without amniotic fluid discordance.
- It can be spontaneous (3-5%) or iatrogenic/postlaser (2-16%).
- Accurate diagnosis is challenged by evolving criteria and potential misdiagnosis.
Conclusions:
- Increased awareness and knowledge of TAPS are essential for timely diagnosis and management.
- Understanding the vascular pathophysiology is key to identifying and treating TAPS effectively.
- Further research into screening protocols and diagnostic markers is needed for MC twin pregnancies.
Keywords:
Twin pregnancyfetofetal transfusionmonochorionic twinstwin anemia polycythemia sequencetwin oligohydramnios-polyhydramnios sequencetwin-to-twin transfusion syndromeMore Related Videos
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