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Related Experiment Videos

Differences in respiratory patterns after acute and chronic pulmonary denervation.

R L Martin-Body1, J D Sinclair

  • 1Department of Physiology, University of Auckland, New Zealand.

Respiration Physiology
|November 1, 1987
PubMed
Summary

Pulmonary vagal nerve activity significantly influences respiratory patterns, but its role extends beyond simple pulmonary stretch receptor input. Chronic denervation causes less pronounced changes in breathing compared to acute procedures.

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Area of Science:

  • Physiology
  • Respiratory Control
  • Neuroscience

Background:

  • Pulmonary vagal nerve activity is crucial for regulating respiratory patterns.
  • The precise mechanisms and extent of vagal influence on breathing remain under investigation.

Purpose of the Study:

  • To investigate the role of pulmonary vagal information in controlling respiratory patterns in rats.
  • To differentiate the effects of acute versus chronic pulmonary denervation on respiratory parameters.
  • To examine respiratory responses to hypercapnia following different vagotomy procedures.

Main Methods:

  • Pulmonary denervation in rats using bilateral cervical vagotomy, or combined cervical vagotomy with pneumonectomy or intrathoracic vagotomy.
  • Assessment of respiratory parameters including tidal volume (VT), inspiratory duration (TI), and expiratory duration (TE) in awake and anesthetized states.

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  • Evaluation of respiratory frequency (f) changes during hypercapnia under various denervation conditions.

    • Main Results:

    • Acute denervation increased VT, TI, and TE in both awake and anesthetized rats; TE increases were transient in awake rats.
    • Chronic denervation resulted in smaller increases in VT and TI, with no change in TE.
    • Hypercapnia induced respiratory frequency increases via TI and TE reductions in awake rats with combined pneumonectomy/vagotomy.
    • Anesthetized rats with acute bilateral vagotomy showed decreased respiratory frequency due to an expiratory pause.

    Conclusions:

    • Vagal activity's role in respiratory patterns involves more than pulmonary stretch receptor input.
    • Vagal influences on expiratory duration (TE) are temporary.
    • Halothane anesthesia combined with hypercapnia induces an expiratory pause.
    • Pneumonectomy with contralateral vagotomy allows awake rat studies, though denervation is less complete than bilateral intrathoracic vagotomy.