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Updated: Aug 12, 2025
A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
[NMDA receptors expression activity in anaplastic astrocytomas]
P V Nikitin1, A Y Belyaev2, G L Kobyakov2
1Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Objective:
To study the relationship of NMDA receptors expression activity with proliferative activity and genetic properties of anaplastic astrocytomas, as well as the survival of patients with this disease.
Material And Methods:
To solve this problem, we compared the expression activity of the least studied NMDA receptors in the context under consideration, detected using immunofluorescent studies and polymerase chain reaction, with the results of histological and molecular studies, the proliferative activity of neoplasms, and the survival of patients.
Results:
The expression activity of NMDA receptors is higher in astrocytomas, grade 3, which do not carry mutations in IDH1 and IDH2 genes. In addition, the activity of NMDA receptors expression directly correlates with proliferative activity in the tumors. The activity of NMDA receptor expression has a significant impact on the prognosis of disease-free survival.
Conclusion:
We have shown for the first time the significant role of NMDA receptors in the progression of diffuse astrocytomas, which can become the basis for creating new therapeutic and diagnostic tools.
Insights
N-methyl-D-aspartate (NMDA) receptor expression is higher in aggressive astrocytomas and correlates with tumor growth. This finding may lead to new diagnostic and therapeutic strategies for diffuse astrocytomas.
Area of Science:
- Neuroscience
- Oncology
- Molecular Biology
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