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Neurodevelopmental disorders (NDD) without boundaries: research and interventions beyond classifications.
Cécile Louveau1, Pierre Ellul2,3, Anton Iftimovici1,4
1GHU-Paris Psychiatrie et Neurosciences, Paris, France.
Journal of Neural Transmission (Vienna, Austria : 1996)
|January 31, 2023
Summary
Neurodevelopmental disorders (NDD) are better understood using a dimensional approach, integrating genetic and environmental factors. This perspective shifts therapeutic strategies for NDD and related psychiatric conditions.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Neurodevelopmental disorders (NDD) are often classified categorically, potentially limiting comprehensive understanding and treatment.
- A dimensional approach offers a more nuanced perspective on NDD, considering a spectrum of symptoms and underlying factors.
Purpose of the Study:
- To explore NDD beyond traditional classifications, adopting a dimensional perspective.
- To discuss research on genetic, environmental, and immune system influences on neurodevelopment.
- To examine the continuum between NDD and adult psychiatric disorders.
Main Methods:
- The content summarizes discussions from the 2nd Webinar "Neurodevelopmental Disorders (NDD) without boundaries."
- Key research areas presented include irritability in NDD, immune system involvement, gut microbiota's role, and co-occurring conditions.
- Discussions also covered genetic mapping, epigenetics, and the autism-schizophrenia continuum.
Main Results:
- Evidence suggests a continuum between NDD and adult psychiatric presentations, influenced by genetic and environmental factors.
- Clinical and imaging features support a dimensional view of NDD.
- Co-occurring conditions in autistic individuals without intellectual disability were examined.
Conclusions:
- A dimensional approach to NDD could revolutionize therapeutic strategies, leading to broader treatments.
- Addressing the complexity and heterogeneity of NDD requires international collaboration.
- Future research and political challenges involve pushing the frontiers of knowledge in NDD.
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