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Updated: Aug 12, 2025

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Is Cirrhotic Cardiomyopathy Related to Cirrhosis Severity?

Subhash Chandra Dash1, Beeravelli Rajesh2, Suresh Kumar Behera3

  • 1Department of General Medicine, Institute of Medical Sciences & SUM Hospital, Bhubaneswar, India.

Rambam Maimonides Medical Journal
|January 31, 2023
PubMed

Insights

Cirrhotic cardiomyopathy (CCM) is more common in severe liver cirrhosis. This study found that cardiac dysfunction, particularly systolic dysfunction, worsens with cirrhosis severity, impacting patient outcomes.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Cirrhotic cardiomyopathy (CCM) is a significant complication of liver cirrhosis, contributing to increased patient morbidity and mortality.
  • The relationship between CCM and the severity of liver cirrhosis remains incompletely understood, with contradictory findings in existing literature.
  • Early diagnosis and understanding of CCM are crucial for managing patients with liver cirrhosis.

Purpose of the Study:

  • To investigate the prevalence of cardiac dysfunction in an Indian population with liver cirrhosis.
  • To explore the correlation between cirrhotic cardiomyopathy and the severity of liver cirrhosis, assessed using MELD and CTP scores.
  • To identify specific patterns of cardiac dysfunction, including systolic and diastolic abnormalities, in patients with cirrhosis.

Main Methods:

  • Ninety-six patients diagnosed with liver cirrhosis but without pre-existing cardiac conditions were enrolled.
  • Participants underwent clinical evaluation, electrocardiography, and echocardiography to assess cardiac function.
  • Cirrhosis severity was quantified using the Model for End-stage Liver Disease (MELD) and Child-Turcotte-Pugh (CTP) scoring systems.

Main Results:

  • Cirrhotic cardiomyopathy was diagnosed in 39.6% of patients.
  • Patients with CCM exhibited significantly higher CTP (9.6±2.6 vs. 8.3±2.3) and MELD (19.72±4.9 vs. 17.41±4.1) scores compared to those without CCM.
  • Systolic dysfunction and reduced left ventricular ejection fraction were more prevalent in advanced stages of cirrhosis (CTP-C).

Conclusions:

  • Cirrhotic cardiomyopathy demonstrates a positive correlation with the severity of liver cirrhosis.
  • Progressive decline in systolic cardiac function is observed as cirrhosis severity increases.
  • Overt systolic dysfunction is particularly common in advanced stages of liver cirrhosis, underscoring the need for cardiac monitoring.
Abstract

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