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Related Experiment Video

Updated: Aug 12, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Hungry bone syndrome after parathyroid surgery.

Ya-Ling Tai¹, Hsin-Yi Shen², Wei-Hsuan Nai¹

¹Department of Nephrology, Clinical Poison Center, Chang Gung Memorial Hospital, Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Hemodialysis International. International Symposium on Home Hemodialysis

|January 31, 2023

Summary

Hungry bone syndrome is common after parathyroidectomy in dialysis patients, occurring in 83.3%. Preoperative ferritin levels may predict its development, necessitating monitoring and management.

Keywords:

calcitriol calcium cinacalcet hungry bone syndrome parathyroid hyperplasia parathyroidectomy

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Area of Science:

Nephrology
Endocrinology
Surgical Oncology

Background:

Inconsistent incidence rates of hungry bone syndrome (HBS) after parathyroidectomy in dialysis patients are reported, ranging from 15.8% to 92.9%.
Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease requiring dialysis.

Purpose of the Study:

To determine the incidence of hungry bone syndrome after parathyroidectomy in patients undergoing hemodialysis.
To identify predictors and clinical characteristics of hungry bone syndrome in this patient population.

Main Methods:

A retrospective study of 120 hemodialysis patients who underwent parathyroidectomy for secondary hyperparathyroidism between 2009 and 2019.
Patients were stratified into groups with and without hungry bone syndrome post-surgery.
Multivariate logistic regression was used to identify predictors of hungry bone syndrome.

Main Results:

Hungry bone syndrome developed in 83.3% of patients, with an average onset of 0.3 months and duration of 11.1 months.
Patients with hungry bone syndrome exhibited lower nadir corrected calcium and parathyroid hormone levels post-surgery.
Preoperative blood ferritin level was identified as a negative predictor for developing hungry bone syndrome (P=0.038).

Conclusions:

Hungry bone syndrome is a frequent complication following parathyroidectomy in dialysis patients with secondary hyperparathyroidism.
Close monitoring and appropriate management strategies are crucial for patients experiencing hungry bone syndrome.
Preoperative ferritin levels may aid in predicting the risk of developing hungry bone syndrome.