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Design and Development of Agglomerated Isomalt
Nikita N Chauhan1, Jayvadan K Patel2
1Nootan Pharmacy College, Sankalchand Patel University, Visnagar, Gujarat, India. chauhan.nikita.nikita@gmail.com.
International Journal of Pharmaceutical Compounding
|January 31, 2023
Summary
Melt granulation effectively produced agglomerated isomalt using glyceryl monostearate. This process maintained isomalt
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Isomalt is a sugar substitute with potential applications in pharmaceuticals.
- Improving the flow properties of isomalt powder is crucial for manufacturing processes.
Purpose of the Study:
- To prepare agglomerated isomalt using a melt granulation process.
- To evaluate the physicochemical properties of the resulting agglomerated isomalt.
Main Methods:
- Melt granulation of isomalt powder with glyceryl monostearate (0.5%) at its melting point.
- Characterization using Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM).
- Evaluation of solubility profiles and flow properties compared to pure isomalt and galenIQ 721.
Main Results:
- Melt granulation successfully produced agglomerated isomalt granules.
- FTIR and DSC confirmed no chemical structure changes in isomalt post-granulation.
- Agglomerated isomalt exhibited similar solubility to galenIQ 721 and improved flow properties.
- SEM analysis indicated promising agglomerate formation.
Conclusions:
- Melt granulation is a viable method for producing agglomerated isomalt with enhanced properties.
- The process preserves the chemical integrity of isomalt.
- Agglomerated isomalt shows potential for pharmaceutical applications due to improved characteristics.
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