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Central GLP-1 Resistance Induced by Severe Traumatic Brain Injury Was Associated with Persistent Hyperglycemia in

Min Zhou1, Min Du1, Rui Tang1

  • 1Neurocritical Care Unit, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.

Neuroendocrinology
|January 31, 2023
PubMed

Insights

Higher plasma glucagon-like peptide-1 (GLP-1) levels in traumatic brain injury (TBI) patients predict mortality. This suggests central resistance to GLP-1 may contribute to hyperglycemia and poor outcomes in TBI survivors.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Critical Care Medicine

Background:

  • The role of the glucagon-like peptide-1 (GLP-1) system in glucose homeostasis following traumatic brain injury (TBI) is not well understood.
  • Investigating GLP-1's potential as a prognostic marker in TBI patients is crucial for understanding outcomes.

Purpose of the Study:

  • To determine if plasma GLP-1 levels can differentiate between survivors and non-survivors within 14 days post-TBI.
  • To assess the association of plasma GLP-1 levels with 6-month mortality in TBI patients.

Main Methods:

  • Examined metabolic, inflammatory, and hematologic profiles in 73 TBI patients.
  • Utilized two-way ANOVA to identify factors discriminating survivors from non-survivors.
  • Employed binary logistic regression and Cox proportional hazard regression to determine biomarkers associated with mortality.

Main Results:

  • Non-survivors exhibited higher 14-day plasma GLP-1, glucose, and IL-6 levels compared to survivors.
  • Lower insulin levels at days 4-7 were observed in non-survivors.
  • GLP-1 levels on days 8-10 and IL-6 on days 1-3 were positively associated with mortality, while insulin on days 4-7 was negatively associated.

Conclusions:

  • Persistent elevated GLP-1 levels in non-survivors may indicate central resistance to GLP-1.
  • This resistance could be linked to progressive hyperglycemia and increased mortality in TBI patients.
  • Plasma GLP-1 levels show potential as a prognostic biomarker in TBI.
Abstract

Keywords:
Cerebrospinal fluidGlucagon-like peptide 1HyperglycemiaInsulin resistanceMortalityTraumatic brain injury

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