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Successful treatment of typhoid fever in children with parenteral ceftriaxone
Z Farid1, N Girgis, A Abu el Ella
1United States Naval Medical Research Unit No. 3, Cairo, Egypt.
Insights
Single daily intramuscular injections of ceftriaxone effectively treated Salmonella typhi septicemia in eight seriously ill children. Patients showed rapid clinical improvement and fever reduction, with no relapses observed during follow-up.
Area of Science:
- Pediatrics
- Infectious Diseases
- Pharmacology
Background:
- Salmonella typhi septicemia poses a significant threat to children's health.
- Effective and accessible treatment options for pediatric typhoid fever are crucial.
Purpose of the Study:
- To evaluate the efficacy of ceftriaxone in treating Salmonella typhi septicemia in children.
- To assess the safety and clinical outcomes of this treatment regimen.
Main Methods:
- A study involving eight seriously ill children with bacteriologically confirmed Salmonella typhi septicemia.
- Treatment administered as a single daily intramuscular injection of 2g ceftriaxone for 5-7 days.
Main Results:
- All eight children demonstrated clinical improvement within 48 hours of initiating ceftriaxone therapy.
- Seven out of eight children became afebrile within 5 days.
- No relapses were recorded during the 4-week follow-up period.
Conclusions:
- Single daily intramuscular ceftriaxone is an effective treatment for pediatric Salmonella typhi septicemia.
- This regimen offers a promising therapeutic option with rapid clinical response and sustained efficacy.
Abstract:
Eight children, seriously ill with bacteriologically proven Salmonella typhi septicemia, were successfully treated with a single daily intramuscular injection of 2 g ceftriaxone given for 5-7 days. All children improved clinically within 48 h of starting therapy and all except 1 became afebrile within 5 days. None relapsed during the 4-week follow-up study.