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Updated: Jun 30, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

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[Clinical analysis of 4 acute ischemic stroke children treated with endovascular thrombectomy]

J J Cao1, Q Di1, G Shen1

  • 1Department of Intervention & Hemangioma, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics
|January 31, 2023
PubMed

Insights

Endovascular thrombectomy (EVT) is a feasible and safe treatment for acute ischemic stroke (AIS) in children with large vessel occlusion, even when initiated after 6 hours. However, children with heart disease face a poorer prognosis.

Area of Science:

  • Pediatric Neurology
  • Interventional Neuroradiology
  • Vascular Neurology

Context:

  • Acute ischemic stroke (AIS) in children is a rare but serious condition.
  • Endovascular thrombectomy (EVT) has emerged as a promising treatment for AIS in adults.
  • The feasibility and safety of EVT in pediatric AIS require further investigation.

Purpose:

  • To evaluate the feasibility and safety of EVT for treating AIS in pediatric patients.
  • To assess the efficacy of EVT in achieving vascular recanalization and improving neurological outcomes.
  • To identify potential complications and risk factors associated with EVT in children.

Summary:

  • This retrospective study analyzed 4 pediatric AIS cases treated with EVT, achieving successful recanalization (mTICI≥2b) in all.
  • Neurological deficits improved significantly post-EVT, with 3 out of 4 patients showing good recovery at 6 months.
  • EVT was technically feasible and safe, with no perioperative complications; however, one patient with congenital heart disease experienced a fatal outcome.

Impact:

  • EVT can be a viable treatment option for pediatric AIS caused by large vessel occlusion, even beyond the standard 6-hour window.
  • The study highlights the importance of considering comorbidities, such as congenital heart disease, which may influence prognosis.
  • Findings support the expanded use of EVT in pediatric stroke care, emphasizing the need for specialized centers and further research.

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