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[Plasma perfusion in life-threatening exogenous poisoning]
T Berning1, T Krummenerl, J Glaser
1Medizinischen Klinik und Poliklinik der Westfälischen Wilhelms-Universität Münster, Abteilung Innere Medizin B.
Schweizerische Medizinische Wochenschrift
|September 12, 1987
Summary
Plasma perfusion effectively treats severe exogenous intoxications by removing toxins. This method avoids blood cell loss and anticoagulation, offering a safe detoxification alternative.
Area of Science:
- Toxicology
- Nephrology
- Critical Care Medicine
Background:
- Severe exogenous intoxications pose significant health risks.
- Existing instrumental detoxification techniques have limitations.
Purpose of the Study:
- To evaluate the efficacy and safety of plasma perfusion for treating severe exogenous intoxications.
Main Methods:
- Plasma perfusion was used to treat 30 patients with severe exogenous intoxications.
- Plasma was separated, perfused through an adsorber (activated charcoal, resin), and returned to the patient.
- Mean perfused plasma volume was 3800 ml per patient per treatment cycle.
Main Results:
- 27 out of 30 patients (90%) were successfully treated.
- Plasma perfusion demonstrated effectiveness in eliminating toxic substances.
- Advantages over hemoperfusion include no blood cell loss and no need for systemic anticoagulation.
Conclusions:
- Plasma perfusion is a safe and effective method for instrumental detoxification in severe exogenous intoxications.
- The technique offers significant advantages over other methods like hemoperfusion.
- Further research into toxikinetics supports its clinical utility.