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Updated: Aug 12, 2025
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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
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Nagashima-type palmoplantar keratoderma: Case series and two novel variants
Mitchell Braun1, Keith A Choate2, Erin F Mathes3
1University of California San Francisco School of Medicine, San Francisco, California, USA.
Pediatric Dermatology
|February 1, 2023
Summary
Nagashima-type palmoplantar keratoderma (PPK) is a genetic skin condition. Identifying new genetic variants and understanding diagnostic challenges, like co-occurring atopic dermatitis, are crucial for effective treatment.
Area of Science:
- Dermatology
- Clinical Genetics
Background:
- Nagashima-type palmoplantar keratoderma (PPK) is an inherited skin disorder.
- It follows an autosomal recessive inheritance pattern.
Observation:
- This study reports on four patients with Nagashima-type PPK.
- Two novel genetic variants associated with the condition were identified.
Findings:
- The study highlights the potential for misdiagnosis of Nagashima-type PPK.
- Concomitant atopic dermatitis can complicate the diagnostic process.
Implications:
- Clinicians should consider Nagashima-type PPK in patients with mild PPK and transgrediens.
- Individualized, multimodal treatment strategies are essential for managing this condition.
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