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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

30.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Related Experiment Video

Updated: Aug 12, 2025

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
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Deciphering Adult Neural Stem Cells with Single-Cell Sequencing.

Yi-Dan Liu1, Ying-Ting Zhu1, Yun-Hong Shi1

  • 1Department of Glaucoma and State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Stem Cells and Development
|February 1, 2023
PubMed
Summary

This review explores adult neural stem cells (NSCs) using single-cell RNA sequencing. Understanding NSC heterogeneity in aging and brain tumors offers insights for brain rejuvenation and neurological disorder treatment.

Keywords:
neural stem cellregenerationsingle-cell RNA sequencingsingle-nucleus RNA sequencing

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Last Updated: Aug 12, 2025

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Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Genomics

Background:

  • Adult neural stem cells (NSCs) reside in specific brain regions, self-renew, and differentiate into neurons, astrocytes, and oligodendrocytes.
  • Cellular heterogeneity and developmental dynamics are crucial for understanding NSC function.

Purpose of the Study:

  • To review recent advancements in single-cell analyses of conventional and unconventional neural stem cells.
  • To discuss NSC heterogeneity, aging-related transcriptional changes, and alterations in brain tumors.

Main Methods:

  • Single-cell RNA sequencing (scRNA-seq) to reconstruct high-resolution transcriptional landscapes.
  • Review of existing literature on single-cell analyses of NSCs.

Main Results:

  • Single-cell RNA sequencing reveals significant heterogeneity within the neural stem cell pool.
  • Transcriptional alterations in aging NSCs and those within brain tumors have been characterized.

Conclusions:

  • A comprehensive understanding of NSCs in physiological and pathological states is essential.
  • Insights gained can guide strategies for rejuvenating the aged brain and restoring function in neurological disorders.