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Association of Fibrinogen With Ischemic Stroke: A Systematic Review and Meta-Analysis

Manoj K Prasad1, Sujeet Marandi1, Brajesh Mishra2

  • 1Internal Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.

Cureus
|February 1, 2023
PubMed

Insights

High fibrinogen levels increase the risk of ischemic stroke. This meta-analysis confirms fibrinogen as a significant risk factor, supporting precision medicine approaches for stroke prevention.

Area of Science:

  • Biomedical research
  • Cardiovascular epidemiology
  • Translational medicine

Background:

  • Ischemic stroke is a complex multifactorial disease requiring precise risk factor identification.
  • Numerous potential risk factors for ischemic stroke require validation.
  • Fibrinogen is a candidate risk factor whose association with ischemic stroke needs robust confirmation.

Purpose of the Study:

  • To validate fibrinogen as a risk factor for ischemic stroke using a meta-analysis.
  • To determine the pooled association between elevated fibrinogen levels and ischemic stroke risk.

Main Methods:

  • Systematic literature search of PubMed, Google Scholar, and Cochrane databases for relevant case-control studies.
  • Inclusion of 10 case-control studies encompassing 6877 cases and 7219 controls.
  • Calculation of pooled odds ratios (ORs) with 95% confidence intervals (CIs) using a random effects model.

Main Results:

  • An elevated level of serum fibrinogen was significantly linked to an increased risk of ischemic stroke under a recessive model (OR: 1.47, 95% CI: 1.19-1.76).
  • The analysis revealed substantial heterogeneity among studies (I² = 78.3%, P = 0.000).
  • Studies included populations from both Asiatic and Caucasian ethnicities.

Conclusions:

  • High serum fibrinogen levels are associated with a significantly increased risk of ischemic stroke.
  • Fibrinogen validation supports its role in precision medicine for ischemic stroke risk stratification.
  • Further research may explore mechanisms linking fibrinogen to stroke pathogenesis.

Keywords:
fibrinogenischemic strokemeta-analysisodds ratiosystematic review

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