Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

217
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
217
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

16
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

739
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
739
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

25.4K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
25.4K
Lipid Digestion01:06

Lipid Digestion

92.5K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
92.5K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

2.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply: Epicardial Adipose Tissue Volume and Coronary Plaque Progression.

JACC. Cardiovascular imaging·2026
Same author

Association of lipoprotein(a) and peripheral artery disease: Findings from The hispanic community health study/study of latinos (HCHS/SOL).

American journal of preventive cardiology·2026
Same author

Automated AI-Based Aortic Measurements From Attenuation Correction CT as an Adjunctive Cardiovascular Risk Biomarker: An International Multicenter Study.

Circulation. Cardiovascular imaging·2026
Same author

Revisiting Perfusion in the Forgotten Right Ventricle: Artificial Intelligence-Enhanced Quantification on PET/CT.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Optimal Antithrombotic Therapy for Peripheral Artery Disease: A Systematic Review and Network Meta-Analysis.

Journal of the American Heart Association·2026
Same author

Ventilation-perfusion (V/Q) scans: trends from medicare part B (2013-2023).

The international journal of cardiovascular imaging·2026

Related Experiment Video

Updated: Aug 12, 2025

The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster
07:21

The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster

Published on: June 8, 2018

11.8K

What is really new in triglyceride guidelines?

Aliza Hussain1, Mahmoud Al Rifai2, Melody Hermel3

  • 1Section of Cardiology, Department of Medicine, Baylor College of Medicine.

Current Opinion in Endocrinology, Diabetes, and Obesity
|February 1, 2023
PubMed
Summary

High triglyceride levels are linked to cardiovascular disease. While many therapies failed, purified EPA (icosapent ethyl) showed benefit in the REDUCE-IT trial for high-risk patients.

More Related Videos

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.1K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.3K

Related Experiment Videos

Last Updated: Aug 12, 2025

The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster
07:21

The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster

Published on: June 8, 2018

11.8K
Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.1K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.3K

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Clinical Trials

Background:

  • Elevated triglycerides (TG) are causally linked to atherosclerotic cardiovascular disease (ASCVD).
  • Most TG-lowering therapies (fibrates, niacin, fish oils) have not demonstrated significant cardiovascular risk reduction in clinical trials.
  • The REDUCE-IT trial is a notable exception, showing benefit with purified EPA (icosapent ethyl).

Approach:

  • Review of landmark clinical trials on TG-lowering therapies.
  • Analysis of updated clinical guidelines for hypertriglyceridemia management.
  • Evaluation of evidence linking TG to ASCVD.

Key Points:

  • Lifestyle interventions and statins are first-line therapies for hypertriglyceridemia.
  • Icosapent ethyl esters are effective in reducing cardiovascular risk in specific high-risk populations.
  • Treatment of secondary causes and optimal glycemic control are crucial.

Conclusions:

  • Therapeutic lifestyle interventions are the first-line treatment for hypertriglyceridemia.
  • Icosapent ethyl offers cardiovascular risk reduction in specific high-risk patient populations.
  • Management of hypertriglyceridemia requires a multi-faceted approach including lifestyle, statins, and potentially targeted therapies.