Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

12.8K
This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
12.8K
RNA Stability01:53

RNA Stability

33.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.8K
Stability of Conjugated Dienes01:28

Stability of Conjugated Dienes

3.5K
Introduction
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
3.5K
Variables Affecting Phosphorescence and Fluorescence01:26

Variables Affecting Phosphorescence and Fluorescence

567
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
567

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxidative addition chemistry of bis(4,5-dimethoxybenzo)-1,2,5,6-tetrathiocin with cyclopentadienyl metal carbonyl complexes and the mechanochemical transformation of CpCo(dmobdt) to [CpCo(dmobdt)]<sub>2</sub>.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Synthesis of P<sup>I</sup>, P<sup>III</sup>, and P<sup>V</sup> Compounds Supported by Bis(benzimidazole)Benzene.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Synthesis of heteropnictogen ligands <i>via</i> P<sup>I</sup> transfer.

Chemical communications (Cambridge, England)·2025
Same author

Pnictogen<sup>III</sup> Dications Supported by BZIMPY Ligands.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

P<sup>I</sup> and P<sup>III</sup> Ions Supported by BZIMPY Ligands.

Chemistry (Weinheim an der Bergstrasse, Germany)·2023
Same author

Triphosphenium salts: air-stable precursors for phosphorus(I) chemistry.

Dalton transactions (Cambridge, England : 2003)·2020

Related Experiment Video

Updated: Aug 12, 2025

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
07:44

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes

Published on: July 6, 2016

11.2K

A remarkably stable acyclic phosphamethine cyanine dye.

Erica M Dionisi1, Justin F Binder2, James H W LaFortune1

  • 1Department of Chemistry, Carleton University, 1125 Colonel By. Dr., Ottawa, Ontario, Canada. charles.macdonald@dal.ca.

Dalton Transactions (Cambridge, England : 2003)
|February 1, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed a stable phosphamethine cyanine dye. This breakthrough overcomes sensitivity issues, enabling practical applications for these phosphorus-based dyes in science and technology.

More Related Videos

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
08:46

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI

Published on: November 22, 2016

7.8K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.8K

Related Experiment Videos

Last Updated: Aug 12, 2025

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
07:44

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes

Published on: July 6, 2016

11.2K
Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
08:46

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI

Published on: November 22, 2016

7.8K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.8K

Area of Science:

  • Organic Chemistry
  • Materials Science
  • Photochemistry

Background:

  • Phosphamethine cyanine dyes are valuable due to their unique optical and electronic properties.
  • However, their widespread application is limited by poor stability towards air and moisture.
  • Existing phosphamethine cyanine dyes are sensitive, hindering benchtop use.

Purpose of the Study:

  • To synthesize and characterize a novel, stable acyclic phosphamethine cyanine dye.
  • To investigate the structural features responsible for enhanced stability.
  • To explore the potential for practical applications of this new class of dyes.

Main Methods:

  • Synthesis of the phosphamethine cyanine dye via a one-pot method.
  • Full characterization including spectroscopic and analytical techniques.
  • Electrochemical analysis using cyclic voltammetry.
  • Computational investigations of electronic structure and orbital stability.

Main Results:

  • An exceptionally stable acyclic phosphamethine cyanine dye was successfully synthesized.
  • Nitrile substituents on the N-heterocyclic framework confer significant air and water stability.
  • The dye exhibits resistance to methylation and sulfuration under harsh conditions.
  • Cyclic voltammetry revealed a high oxidation potential, and computational studies indicated stabilized orbitals.
  • The P(I) center demonstrated poor nucleophilicity and resistance to oxidation.

Conclusions:

  • The developed phosphamethine cyanine dye overcomes the inherent instability limitations.
  • Nitrile functionalization is a key strategy for enhancing dye stability.
  • This stable dye is prepared using a convenient one-pot, mild synthesis.
  • The findings pave the way for broader applications of phosphamethine cyanine dyes.