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Metabolic reprogramming heterogeneity in chronic kidney disease
Verónica Miguel1, Rafael Kramann1
1Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, Aachen, Germany.
FEBS Open Bio
|February 1, 2023
Summary
Metabolic reprogramming significantly influences kidney fibrosis by altering cell metabolism. Understanding these fibrometabolic shifts is crucial for developing new therapeutic strategies for chronic kidney disease (CKD).
Area of Science:
- Nephrology
- Metabolic pathways
- Cellular biology
Background:
- Chronic kidney disease (CKD) is characterized by fibrosis, an excessive accumulation of extracellular matrix (ECM).
- Myofibroblasts drive ECM production, activated by interactions with injured kidney cells and immune cells.
- Metabolic alterations are increasingly recognized as key drivers in the development of renal fibrosis.
Purpose of the Study:
- To review the main metabolic reprogramming outcomes in renal fibrosis.
- To explore the role of cell-type-specific metabolic shifts in the fibrogenic response.
- To provide a future perspective on renal fibrometabolism.
Main Methods:
- Review of emerging evidence on metabolic alterations in renal fibrosis.
- Analysis of omics technologies applied to cell-tracing animal models.
- Integration of functional data to understand cell-specific metabolic roles.
Main Results:
- Cell-type-specific metabolic reprogramming plays a significant role in the fibrotic response within the kidney.
- Metabolic shifts are not merely a feature but actively contribute to the pathogenesis of renal fibrosis.
- Specific metabolic pathways are altered during the development and progression of kidney fibrosis.
Conclusions:
- Metabolic reprogramming is a critical factor in renal fibrosis.
- Targeting fibrometabolism offers a promising avenue for future therapeutic interventions in CKD.
- Further research into cell-specific metabolic changes is needed to fully understand and combat kidney fibrosis.
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