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A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity
Dan Zhang1, Sifan Wang1, Fangxi Yang1
1School of Chemical Engineering, Sichuan University, Chengdu 610065, P. R. China. lyf471@vip.163.com.
Abstract:
The responses of a reaction-based fluorescent probe BI-Py towards alkyl halide, epoxide, carbonate, sulfate, sulphonate and triflate were evaluated and the probe achieved selective detection of ethyl triflate in acetonitrile with a LOD of 1.08 μM. BI-Py exhibited great potential for detecting triflate as a genotoxic impurity in drug substances.

