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Related Experiment Videos

Heparin utilization during arterial revascularization.

G J Collins, D B Kimball, N M Rich

    The American Surgeon
    |December 1, 1978
    PubMed
    Summary
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    Therapeutic heparin levels are achieved during vascular surgery with 100 or 150 u/kg doses. Reversing heparin with protamine sulfate prevents prolonged anticoagulation in patients post-procedure.

    Area of Science:

    • Vascular Surgery
    • Anesthesiology
    • Pharmacology

    Background:

    • Peripheral vascular reconstructive procedures often require heparin anticoagulation.
    • Maintaining adequate anticoagulation while minimizing bleeding risk is crucial.
    • Heparin's effects need careful management post-procedure.

    Purpose of the Study:

    • To determine effective pre-procedural heparin dosages for vascular surgery.
    • To assess the duration of therapeutic heparin levels.
    • To evaluate the necessity and method for reversing heparin's effects.

    Main Methods:

    • Administration of two different heparin dosages (100 u/kg and 150 u/kg) before arterial or aortic cross-clamping.
    • Monitoring of heparin levels during peripheral vascular reconstructive procedures.

    Related Experiment Videos

  • Assessment of heparin reversal using protamine sulfate.

    • Main Results:

    • Both 100 u/kg and 150 u/kg heparin doses achieve therapeutic levels during procedures.
    • Adequate heparin levels are maintained for at least one hour, even with the lower dose.
    • Unreversed heparin can lead to prolonged anticoagulation, necessitating protamine sulfate administration.

    Conclusions:

    • Heparin dosing of 100 u/kg or 150 u/kg is effective for peripheral vascular reconstruction.
    • Protamine sulfate administration is recommended to reverse heparin's effects and prevent postoperative anticoagulation.
    • Careful dosing of protamine sulfate is essential to avoid unbound protamine's adverse effects.