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[Retarding progression of chronic kidney disease]
Turgay Saritas1, Jürgen Floege2
1Klinik für Nieren- und Hochdruckkrankheiten, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland. tsaritas@ukaachen.de.
Innere Medizin (Heidelberg, Germany)
|February 1, 2023
Summary
Chronic kidney disease (CKD) is a growing global health concern. Early detection and management, including lifestyle changes and targeted therapies like RAAS inhibitors, are crucial for slowing progression and improving outcomes.
Area of Science:
- Nephrology
- Public Health
Context:
- Chronic kidney disease (CKD) affects 10-15% of the German population, with increasing prevalence.
- CKD is projected to be the 5th leading cause of death globally by 2040.
- CKD is linked to increased mortality, cardiovascular disease, and significant healthcare costs.
Purpose:
- To outline current clinical strategies for managing CKD.
- To highlight the importance of lifestyle modifications and pharmacological interventions.
- To emphasize patient education and multidisciplinary care in managing CKD.
Summary:
- Management strategies include lifestyle changes (weight normalization, reduced protein/salt intake, exercise, smoking cessation).
- Pharmacological treatments involve renin-angiotensin-aldosterone system (RAAS) inhibitors, SGLT-2 inhibitors, and control of risk factors (proteinuria, hyperglycemia, lipids).
- Aldosterone inhibition and avoidance of nephrotoxic agents are also key therapeutic options.
Impact:
- Effective CKD management can slow disease progression and reduce associated mortality and morbidity.
- Patient education and self-empowerment are vital due to the often asymptomatic nature of early CKD.
- Multidisciplinary team-based care is essential for stemming the tide of advanced kidney damage.
Keywords:
HypertensionLifestyle modificationsProteinuriaRenin-angiotensin-aldosterone systemSodium-glucose transporter 2 inhibitorsMore Related Videos
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