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Relationship between elevated bilirubin levels and enhanced warfarin effects during biliary obstruction

Takafumi Nakazawa1,2, Shingo Yamazaki1, Masashi Uchida1,2

  • 1Division of Pharmacy, Chiba University Hospital, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8677, Japan.

European Journal of Clinical Pharmacology
|February 1, 2023
PubMed
Summary

Biliary obstruction significantly prolongs prothrombin time-international normalized ratio (PT-INR) in warfarin users. Elevated bilirubin levels strongly correlate with this PT-INR increase, necessitating careful monitoring for safe warfarin therapy.

Keywords:
Biliary obstructionBilirubinPT-INRWarfarin

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