Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

31
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
31
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

46
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
46

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining Structural and Social Drivers of Human Papillomavirus Vaccination Rates Across Clinical Settings for Youth.

Journal of pediatric and adolescent gynecology·2026
Same author

CUI-MET: A Clinical Utility Index Based Analysis and Decision Framework for Dose Optimization in Multiple-Dose, Multiple-Outcome Randomized Trials.

Pharmaceutical statistics·2026
Same author

Isolation and functional characterization of primary human proximal tubular epithelial cells from brain-dead organ donors.

Physiological reports·2026
Same author

Direct Measurement of Organ Procurement Organization Donor Potential Using Comprehensive Referral Analysis: Feasibility and Implications for Assessing Organ Procurement Organization Performance.

Transplantation·2026
Same author

Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation.

Trends in pharmacological sciences·2026
Same author

Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients.

The New England journal of medicine·2026

Related Experiment Video

Updated: Aug 12, 2025

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.2K

Hypothermia or Machine Perfusion in Kidney Donors.

Darren Malinoski1, Christina Saunders1, Sharon Swain1

  • 1From the Division of Trauma, Critical Care, and Acute Care Surgery, Oregon Health and Science University (D.M., T.G., R.N.), and the Pacific Northwest Transplant Bank (C.V.D.W.) - both in Portland; Berry Consultants, Austin (C.S., K.B.), LifeGift, Houston (P.R.W.), and South West Transplant Alliance, Dallas (J.R.) - all in Texas; Donor Alliance, Denver (J.P.); LifeSource, Minneapolis (K.K.); Donor Network Arizona, Tempe (P.J.G.); and Donor Network West, San Ramon (S.S.), and the Department of Anesthesia and Perioperative Care and the Department of Surgery, Division of Transplantation (C.U.N.), University of California, San Francisco - both in California.

The New England Journal of Medicine
|February 1, 2023
PubMed
Summary

Therapeutic hypothermia in organ donors was less effective than machine perfusion at preventing delayed graft function in kidney transplant recipients. Combining both methods offered no additional benefit over machine perfusion alone.

More Related Videos

Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

11.7K
Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

7.3K

Related Experiment Videos

Last Updated: Aug 12, 2025

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.2K
Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

11.7K
Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

7.3K

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Organ preservation

Background:

  • Therapeutic hypothermia in brain-dead organ donors may reduce delayed graft function in kidney transplant recipients.
  • Comparative data on hypothermia versus machine perfusion for kidney transplant outcomes are needed.

Purpose of the Study:

  • To compare the efficacy of therapeutic hypothermia versus ex situ kidney hypothermic machine perfusion in reducing delayed graft function.
  • To evaluate the combination of both therapies and their superiority over individual methods.

Main Methods:

  • Randomized trial at six US organ-procurement facilities.
  • Brain-dead kidney donors assigned to therapeutic hypothermia, hypothermic machine perfusion, or both.
  • Primary outcome: delayed graft function (dialysis within 7 days post-transplant).

Main Results:

  • Delayed graft function occurred in 30% of hypothermia group, 19% of machine-perfusion group, and 22% of combination-therapy group.
  • Therapeutic hypothermia was inferior to machine perfusion (risk ratio 1.72).
  • Combination therapy was not superior to machine perfusion (risk ratio 1.09).

Conclusions:

  • Therapeutic hypothermia is inferior to machine perfusion for reducing delayed graft function in kidney transplantation.
  • Combining hypothermia with machine perfusion does not offer additional protection.
  • Graft survival at 1 year was similar across all groups.