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Updated: Aug 12, 2025

Isolation of F1-ATPase from the Parasitic Protist Trypanosoma brucei
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P5-ATPases: Structure, substrate specificities, and transport mechanisms

Sue Im Sim1, Eunyong Park2

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Current Opinion in Structural Biology
|February 1, 2023
PubMed
Summary

P5-ATPases transport substrates in the endoplasmic reticulum and endo-/lysosomes. Recent studies reveal their unique mechanisms for extracting transmembrane helices and exporting polyamines.

Keywords:
Endoplasmic reticulumKufor Rakeb syndromeLysosomesP-type ATPasesP5-ATPasesParkinson's diseasePolyamineProtein quality controlTail-anchored membrane proteins

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