Related Experiment Video
Updated: Aug 12, 2025

Cross-Modal Multivariate Pattern Analysis
Published on: November 9, 2011
Multimodal integration and modulation of visual and somatosensory inputs on the corticospinal excitability
Fatma Gokcem Yildiz1, Cagri Mesut Temucin2
1Faculty of Medicine, Department of Neurology, Hacettepe Univesity, EMG-TMS Unit, Ankara, Turkey; Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, Turkey.
Objective:
Corticospinal excitability may be affected by various sensory inputs under physiological conditions. In this study, we aimed to investigate the corticospinal excitability by using multimodal conditioning paradigms of combined somatosensory electrical and visual stimulation to understand the sensory-motor integration.
Methods:
We examined motor evoked potentials (MEP) obtained by using transcranial magnetic stimulation (TMS) that were conditioned by using a single goggle-light-emitting diode (LED) stimulation, peripheral nerve electrical stimulation (short latency afferent inhibition protocol), or a combination of both (goggle-LED+electrical stimulation) at different interstimulus intervals (ISIs) in 14 healthy volunteers.
Results:
We found MEP inhibition at ISIs of 50-60 ms using the conditioned goggle-LED stimulation. The combined goggle-LED stimulation at a 60 ms ISI resulted in an additional inhibition to the electrical stimulation.
Conclusions:
Visual inputs cause significant modulatory effects on the corticospinal excitability. Combined visual and somatosensory stimuli integrate probably via different neural circuits and/or interneuron populations. To our knowledge, multimodal integration of visual and somatosensory inputs by using TMS-short latency inhibition protocol have been evaluated via electrophysiological methods for the first time in this study.
Related Concept Videos
Somatosensation
Somatosensory, Motor, and Association Cortex
Overview of Somatic Sensory Pathways
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Major Somatic Sensory Pathways
Sensory Perception: Organization of the Somatosensory System
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
Motor and Sensory Areas of the Cortex
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....

