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Precipitation Gravimetry

Precipitation Gravimetry

Precipitation gravimetry is based on converting an analyte into a sparingly soluble precipitate, which is separated by filtration and weighed. An ideal precipitate should be pure, insoluble, of known composition, and easily filtered from the reaction mixture.
In determining nickel by gravimetric analysis, a precipitant of ethanolic dimethylglyoxime is added to a hot nickel salt solution. This is quickly followed by the dropwise addition of dilute ammonia solution until precipitation occurs. A...

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Quantification of Risperidone Contained in Precipitates Produced by Tea Catechins Using Nuclear Magnetic Resonance.

Takeshi Goromaru¹, Kai Fujita¹, Misaki Mizumoto¹

¹Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University.

Chemical & Pharmaceutical Bulletin

|February 1, 2023

Summary

This summary is machine-generated.

Risperidone efficacy may decrease when taken with tea. Gallated catechins, especially EGCg and ECg, bind to risperidone, forming precipitates and reducing drug availability.

Keywords:

(−)-epicatechin (−)-epigallocatechin-3-O-gallate Catechin Mixture gallated catechin quantitavie (q)NMR risperidone

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Area of Science:

Pharmacology
Analytical Chemistry
Food Science

Background:

Risperidone is an antipsychotic medication.
Tea catechins are antioxidants found in tea.
Interactions between medications and dietary components can affect drug efficacy.

Purpose of the Study:

To investigate the precipitation interaction between risperidone and major tea catechins.
To quantify the amounts of risperidone and catechins involved in precipitate formation.
To determine which specific catechins are responsible for precipitating risperidone.

Main Methods:

A mixture of risperidone and eight major tea catechins was prepared in a tartaric acid buffer.
Precipitates were formed and collected.
Quantitative 1H-NMR (qNMR) was used to measure the amounts of risperidone and catechins in the precipitates.

Main Results:

Gallated catechins (ECg, EGCg, Cg, GCg) precipitated risperidone significantly, while non-gallated catechins (EC, EGC, CA, GC) did not.
2,3-cis gallated catechins (EGCg, ECg) were more effective in precipitating risperidone than 2,3-trans gallated catechins (Cg, GCg).
EGCg and ECg were identified as the primary catechins responsible for risperidone precipitation.

Conclusions:

The efficacy of risperidone may be reduced when co-administered with catechin-rich beverages.
2,3-cis gallated catechins, specifically EGCg and ECg, form complexes with risperidone, leading to precipitation.
This interaction highlights the importance of considering dietary components in medication management.