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Immunological effects of arsenic compounds on mouse spleen cells in vitro
T Yoshida1, T Shimamura, S Shigeta
1Department of Microbiology, Tokai University School of Medicine, Japan.
The Tokai Journal of Experimental and Clinical Medicine
|November 1, 1986
Abstract:
Immunological effects of arsenic compounds on mouse spleen cells in vitro were examined. Three kinds of arsenic compounds: sodium arsenite, sodium arsenate and dimethyl arsenic acid, at high doses, suppressed the plaque-forming cell response to sheep erythrocytes and the proliferative response to mitogens, whereas at low doses they enhanced both responses. And each of arsenic compounds differs in strengths at which the modulation effects on both responses were exerted. The strength was comparable to general toxicity of arsenic compounds.