The direct correlation between microbiota and SARS-CoV-2 infectious disease

Area of Science:

• Microbiology
• Immunology
• Virology

Background:

• The human microbiota, comprising symbiotic microorganisms, is crucial for physiological functions.
• Altered microbiota is linked to chronic inflammatory, psychiatric, and infectious diseases.
• The microbiota's role in host immune response to infections is not fully understood.

Purpose of the Study:

• To review the association between microbiota and COVID-19 infection.
• To highlight the biological and clinical significance of microbiota alterations in COVID-19.
• To emphasize mechanisms of microbiota-derived metabolites in modulating immune responses to COVID-19.

Main Methods:

• Literature review of studies on microbiota and COVID-19.
• Analysis of mechanisms involving microbial metabolites and host immunity.
• Examination of clinical and biological significance.

Main Results:

• Evidence suggests microbiota is altered in patients with viral infections, including post-acute COVID-19 syndrome (PACS).
• Microbiota-host interactions are mediated by microbial metabolites.
• These metabolites influence the host's immune capacity.

Conclusions:

• Microbiota plays a significant role in the host immune response to infections like COVID-19.
• Microbial metabolites are key mediators in the interplay between microbiota and COVID-19.
• Understanding these interactions is crucial for managing COVID-19 and related syndromes.