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Learnings in developmental and epileptic encephalopathies: what do we know?
Martina Giorgia Perinelli1,2, Antonella Riva1,2, Elisabetta Amadori1,2
1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Expert Review of Neurotherapeutics
|February 2, 2023
Summary
Developmental and Epileptic Encephalopathies (DEEs) cause cognitive dysfunction. Early neurorehabilitation interventions are crucial for improving outcomes in patients with DEEs.
Area of Science:
- Neurology
- Developmental Neuroscience
Background:
- Developmental and Epileptic Encephalopathies (DEEs) are neurological disorders impacting neuronal development and cognitive function.
- Patients with DEEs often experience seizures, learning difficulties, behavioral issues, and speech delays.
Approach:
- A comprehensive literature review was conducted using Medline/PubMed.
- Searched for English articles published between 1967 and 2022 on DEEs and cognitive development.
- Included reviews, randomized clinical trials, and case reports, with independent screening by two authors.
Key Points:
- Scientific literature lacks explicit focus on early neuro-psychomotor rehabilitation and neuropsychological assessment for DEEs.
- Targeted interventions and environmental stimuli can positively influence neuronal circuit maturation.
- Early interventions are most effective during critical developmental periods.
Conclusions:
- Early neurorehabilitation interventions hold significant potential for improving the quality of life for DEE patients.
- Implementing these interventions can reduce the psychosocial burden on families and caregivers.
- Further research and clinical application of early interventions are warranted.
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