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Henle fiber layer hemorrhage as the first manifestation of factor V Leiden homozygous mutation
Ana Flores-Márquez1, Juan Ángel Moreno-Gutiérrez1, Susana García-Marcet1
1Department of Ophtalmology, Hospital Costa del Sol, Marbella, Spain.
Purpose:
To report a case of a Henle fiber layer hemorrhage as the initial manifestation of Factor V Leiden disease.
Methods:
Case report and literature review.
Results:
A healthy 19-year-old patient presented with a spontaneous Henle fiber layer (HFL) hemorrhage. The genetic analysis showed a previously unknown homozygous Factor V Leiden Mutation. No specific treatment was given due to the patient's good visual acuity and favorable prognosis, but the diagnosis of a Factor V Leiden mutation enabled a correct therapeutic management to be followed by the patient.
Conclusion:
Advances in eye imaging allow to detect ocular findings that may lead to an early diagnosis and treatment. To the best of our knowledge, this is the first case of a HFL hemorrhage as the initial manifestation of Factor V Leiden disease. Further research is needed to identify the pathways linking these findings.
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