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Cardiac Rhabdomyoma in Four Göttingen Minipigs.

Laine E Feller1,2, Aaron Sargeant3, E J Ehrhart3

  • 1Cornell University, Ithaca, New York, USA.

Toxicologic Pathology
|February 2, 2023
PubMed
Summary

This study reports the first cases of cardiac rhabdomyoma, a rare benign heart tumor, found in Göttingen minipigs used in toxicology studies. These incidental findings highlight a new consideration for this important animal model.

Keywords:
cardiovascular systemcell proliferationdevelopmental pathologyminipignomenclaturesafety assessmenttumors

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Area of Science:

  • Veterinary Pathology
  • Toxicology
  • Cardiovascular Research

Background:

  • Göttingen minipigs are a significant large animal model in nonclinical toxicology.
  • Proloferative lesions are uncommon in this species.
  • Cardiac rhabdomyomas are benign cardiac tumors with known occurrences in other species.

Purpose of the Study:

  • To document the occurrence and characteristics of cardiac rhabdomyomas in Göttingen minipigs.
  • To assess the clinical significance of these lesions in the context of toxicology studies.
  • To contribute to the understanding of spontaneous lesions in this laboratory animal model.

Main Methods:

  • Retrospective review of necropsy and histopathology findings in Göttingen minipigs.
  • Gross examination of cardiac tissues.
  • Microscopic evaluation of cardiac lesions, including cellular morphology and staining characteristics (PAS).

Main Results:

  • Four cases of cardiac rhabdomyoma were identified in Göttingen minipigs.
  • Lesions ranged from microscopic nodules to a large, palpable mass on a papillary muscle.
  • Histopathology revealed characteristic features of rhabdomyoma, including vacuolated cells with cross-striations.
  • No clinical signs of cardiac insufficiency were associated with the tumors.

Conclusions:

  • Spontaneous cardiac rhabdomyoma is a newly identified, incidental finding in Göttingen minipigs.
  • These benign lesions are unlikely to impact the outcome of toxicology studies.
  • This report expands the known spontaneous pathology of Göttingen minipigs.