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Association of Serum Pentraxin 3 and High-Sensitivity C-Reactive Protein with Severity of Coronary Stenosis

Sujatha Mahadevarao Premnath1, Sunil Kumar Nanda1, Lopamudra Ray2

  • 1Department of Biochemistry, Pondicherry Institute of Medical Science, Pondicherry University, Puducherry, India.

International Journal of Applied & Basic Medical Research
|February 2, 2023
PubMed

Insights

Pentraxin 3 (PTX3) strongly correlates with coronary artery disease (CAD) severity, offering a potential alternative to angiography. High-sensitivity C-reactive protein (hs-CRP) shows a weaker association with CAD progression.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Coronary artery disease (CAD) is linked to atherosclerosis, a chronic inflammatory condition.
  • Pentraxin 3 (PTX3) and high-sensitivity C-reactive protein (hs-CRP) are key inflammatory markers associated with atherosclerosis.

Purpose of the Study:

  • To investigate the relationship between serum PTX3 and hs-CRP levels and the severity of coronary stenosis.
  • To assess the predictive value of PTX3 and hs-CRP in patients undergoing coronary angiography.

Main Methods:

  • Eighty patients undergoing elective coronary angiography had blood samples collected for PTX3 and hs-CRP analysis.
  • Patients were categorized into four groups based on the number of affected coronary arteries.
  • PTX3 and hs-CRP levels were measured using enzyme-linked immunosorbent assay and latex-enhanced immunosorbent assay, respectively.

Main Results:

  • PTX3 levels increased significantly with the severity of coronary stenosis (P = 0.000).
  • A strong positive correlation was found between PTX3 and stenosis severity (R = 0.7929, P < 0.00001).
  • hs-CRP showed a weaker positive correlation with stenosis severity (R = 0.3011, P = 0.006).

Conclusions:

  • PTX3 and hs-CRP can predict the number of affected coronary arteries.
  • These biomarkers may help differentiate between normal coronaries and CAD, potentially reducing the need for angiography.
Abstract

Keywords:
AtherosclerosisPentraxin 3coronary stenosishigh-sensitivity C-reactive protein

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