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Related Concept Videos

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T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Related Experiment Video

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Targeting type I interferons in systemic lupus erythematous.

Sebastian Bruera1, Thandiwe Chavula1, Riya Madan2

  • 1Section of Immunology, Allergy and Rheumatology, Department of Medicine, Baylor College of Medicine, Houston, TX, United States.

Frontiers in Pharmacology
|February 2, 2023
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Summary

Type I interferon (IFN) plays a key role in systemic lupus erythematosus (SLE) pathogenesis. Targeting this pathway offers new therapeutic strategies and biomarker potential for SLE patients.

Keywords:
dendritic cellinterferonslupus (SLE)rheumatologytreatment

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Area of Science:

  • Immunology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with diverse clinical features.
  • Autoantibodies and immune complexes are established drivers of lupus, but the type I interferon (IFN) pathway is increasingly recognized for its significant role.

Purpose of the Study:

  • To review the role of type I IFN in the pathogenesis of SLE.
  • To explore the translational potential of type I IFN as a biomarker and therapeutic target in SLE.

Main Methods:

  • This is a narrative review.
  • The review synthesizes current research on type I IFN in SLE pathogenesis and therapeutic development.

Main Results:

  • Type I IFN signaling is a critical component of SLE pathogenesis in both patients and animal models.
  • Targeting type I IFN pathways has led to the development of novel therapeutics for specific SLE manifestations.

Conclusions:

  • Type I IFN is a crucial factor in SLE pathogenesis.
  • Type I IFN represents a promising biomarker and therapeutic target for managing SLE.