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Heparin-Binding Protein: A Prognostic Biomarker Associated with Severe or Complicated Community-Acquired Pneumonia in
Shuang Li1,2, Yanwen Xu2, Yuhang Wu2
1Department of Infectious Diseases, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, People's Republic of China.
Insights
Elevated serum heparin-binding protein (HBP) in children with community-acquired pneumonia (CAP) indicates a higher risk of severe disease and poor prognosis. This finding suggests HBP may be a valuable biomarker for assessing CAP severity.
Area of Science:
- Pediatric Infectious Diseases
- Biomarker Discovery
- Inflammatory Disease Research
Background:
- Heparin-binding protein (HBP) is recognized as a novel biomarker for various inflammatory conditions.
- Community-acquired pneumonia (CAP) in children presents a significant health challenge, necessitating improved diagnostic and prognostic tools.
Purpose of the Study:
- To investigate the role of serum HBP in pediatric CAP.
- To assess the association between HBP levels and CAP severity and prognosis.
Main Methods:
- Retrospective analysis of 125 children hospitalized with CAP.
- Correlation analysis of HBP levels with clinical characteristics and inflammatory markers.
- Receiver operator characteristic (ROC) curve analysis and multivariate logistic regression to evaluate HBP's predictive performance.
Main Results:
- Children with upper-quartile HBP concentrations (≥60 ng/mL) had a significantly higher rate of severe or complicated CAP (54.8% vs. 26.6%).
- HBP levels correlated with neutrophil counts, CRP, ESR, and serum amyloid A.
- Higher HBP concentration was associated with a three-fold increased risk of severe/complicated CAP (aOR=3.11).
- A predictive model including HBP demonstrated an AUC of 0.75 for severe CAP.
Conclusions:
- Elevated serum HBP is significantly associated with severe or complicated CAP and poorer outcomes in children.
- HBP shows potential as a valuable biomarker for predicting CAP severity in pediatric patients.
- Further research into HBP's role in CAP pathogenesis is warranted.
Purpose:
Heparin-binding protein (HBP) is a novel biomarker for inflammatory diseases. This study aimed to investigate the role of serum HBP in community-acquired pneumonia (CAP) in children and the association of HBP with the severity and prognosis.
Patients And Methods:
A total of 125 children with CAP admitted to the hospital were enrolled in this retrospective study. We analyzed the differences in clinical characteristics and examination findings between patients with different levels of HBP. The severe or complicated CAP was defined as having severe radiographic findings and/or systemic manifestations. Receiver operator characteristic (ROC) curves detected the performance of biomarkers in identifying patients with severe or complicated pneumonia. The multivariate logistic regression models assessed the association between HBP levels and the severity and prognosis. Finally, we constructed a predictive model based on HBP.
Results:
The rate of severe or complicated CAP for patients with upper-quartile HBP concentration (≥60 ng/mL) was 54.8%, significantly higher than that of patients with lower HBP concentration (26.6%). The level of HBP is substantially correlated with neutrophil counts, C-reactive protein, erythrocyte sedimentation rate, and serum amyloid A protein (r = 0.31, 0.26, 0.36, and 0.26, respectively). HBP achieved the highest level of discrimination for severe or complicated CAP among the biomarkers. Higher HBP concentration (≥60 ng/mL) was associated with a three-fold higher risk of severe or complicated CAP (adjusted odds ratio = 3.11, p < 0.05). A predictive model including four characteristics (HBP, lactate dehydrogenase, age and non-viral infection) for predicting severe or complicated CAP (with area under the ROC curve = 0.75) was built to create a nomogram.
Conclusion:
Substantially elevated serum HBP is significantly associated with severe or complicated CAP and poor prognosis in children. This finding warrants further investigation of the function of HBP in the pathogenesis of CAP.
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