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Updated: Aug 12, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

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Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Sarfraz Ahmed1, Muhammad Zeeshan Ahmed2,3, Safa Rafique3

  • 1Department of Basic Sciences, University of Veterinary and Animal Sciences Lahore, Narowal Campus, 51600 Narowal, Pakistan.

Biomed Research International
|February 2, 2023
PubMed

Insights

Antimicrobial resistance (AMR) is a growing global threat impacting human and animal health. New therapeutic strategies are crucial to combat resistant infections and reduce mortality rates.

Area of Science:

  • Public Health
  • Microbiology
  • Infectious Diseases

Background:

  • Antimicrobial resistance (AMR) poses a significant global health challenge, complicating infection treatment and increasing mortality.
  • High antimicrobial drug utilization in human and veterinary medicine, agriculture, and vaccination reluctance contribute to AMR gene emergence and spread.

Purpose of the Study:

  • To review current and emerging therapeutic strategies to combat antimicrobial resistance.
  • To highlight the need for novel treatments to reduce reliance on traditional antibiotics and mitigate resistance pressure.

Main Methods:

  • Review of current literature on antimicrobial resistance.
  • Analysis of emerging therapeutic avenues such as antivirulent therapy, phage therapy, and nanotechnology.
  • Discussion of advancements in diagnostics and antimicrobial susceptibility testing.

Main Results:

  • Several promising alternative therapies are emerging to combat AMR, including antimicrobial peptides, vaccines, and phage therapy.
  • These novel approaches aim to reduce the selective pressure exerted by conventional antibiotics.
  • Advancements in diagnostics and understanding antimicrobial pharmacodynamics are key to effective AMR management.

Conclusions:

  • Combating AMR requires a multi-faceted approach, integrating novel therapeutics with improved diagnostics and antimicrobial stewardship.
  • Future research should focus on maintaining host homeostasis during AMR infections and exploring diverse therapeutic modalities.
  • A combination of advanced antimicrobial drugs and innovative treatments is essential to overcome microbial resistance.

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