Related Experiment Video
Updated: Aug 12, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Establishing a core outcomes set for massive transfusion: An Eastern Association for the Surgery of Trauma modified
Rondi B Gelbard1, Jeffry Nahmias, Saskya Byerly
1From the Division of Trauma and Acute Care Surgery, Department of Surgery (R.B.G., J.B.H., J.K.), University of Alabama at Birmingham, Birmingham, Alabama; Division of Trauma, Burns and Surgical Critical Care (J.N.), University of California, Irvine, Orange, California; Department of Surgery (S.B.), University of Tennessee Health Science Campus, Memphis, Tennessee; Department of Surgery (M.Z.), University of Manitoba, Winnipeg, Manitoba, Canada; Department of Surgery (D.S.), R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine; Division of Acute Care Surgery, Department of Surgery (E.R.H.), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Surgery (J.W.S.), University of Louisville School of Medicine, Louisville, Kentucky; Division of Trauma, Acute Care and Critical Care Surgery, Department of Surgery (M.B.), Penn State Hershey Medical Center, Hershey, Pennsylvania; Department of Surgery (B.Z.), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Department of Pathology and Molecular Medicine (J.C.), School of Medicine, Queen's University, Kingston, Ontario, Canada; Department of Surgery (B.A.C.), University of Texas Health McGovern Medical School, Houston, Texas; Department of Surgery (M.C.), University of Colorado Hospital, Aurora, Colorado; Department of Surgery (O.L.G.), Division of Acute Care Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Surgery (L.Z.K.), Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California; Ernest E Moore Shock Trauma Center at Denver Health (E.E.M., D.D.Y.), University of Colorado Denver, Denver, Colorado; Department of Surgery (C.M.R.), Brooke Army Medical Center, San Antonio, Texas; Department of Surgery (M.S.), Oregon Health and Science University, Portland, Oregon; and Department of Surgery (J.L.S.), UPMC Presbyterian, Pittsburgh, Pennsylvania.
Researchers developed a core outcome set (COS) for massive transfusion (MT) research. This standardized set will improve data pooling and statistical power in future studies on severe hemorrhage management.
Area of Science:
- Trauma and Emergency Medicine
- Clinical Research Methodology
Background:
- Severe hemorrhage management has evolved, leading to inconsistent outcome reporting in research.
- Heterogeneous outcome data hinders effective data pooling and meta-analysis in massive transfusion (MT) studies.
Purpose of the Study:
- To develop a core outcome set (COS) for massive transfusion (MT) research.
- To standardize outcome reporting and facilitate data pooling in future MT clinical trials.
Main Methods:
- A modified Delphi study involving massive transfusion content experts.
- Iterative survey rounds with a 9-point Likert scale to achieve consensus on core outcomes.
- Consensus defined as >85% of scores 7-9 and <15% scores 1-3.
Main Results:
- 12 of 16 experts completed three rounds of deliberation.
- 64 items were evaluated, with 4 achieving consensus.
- The 4 core outcomes include: blood products in first 6 hours, 6-hour mortality, time to mortality, and 24-hour mortality.
Conclusions:
- A consensus-based core outcome set (COS) for MT research has been established.
- This COS will standardize outcome measurement in future MT trials.
- The COS will enhance statistical power through improved data pooling capabilities.
More Related Videos
Related Concept Videos
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

