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Published on: September 22, 2023
Factors Affecting Delayed Gastric Emptying and Long-Term Outcomes of Children With Gastric Emptying
Christopher Roberts1, Maryam Hussein1,2, Esme Poole1,2
1From the Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
Insights
Prior abdominal surgery is a key predictor of delayed gastric emptying (DGE) in children. Symptoms and medication needs significantly decreased two years after treatment, indicating positive patient response.
Area of Science:
- Pediatric Gastroenterology
- Diagnostic Imaging
Background:
- Delayed gastric emptying (DGE) affects children, impacting their well-being.
- Identifying predictive factors for DGE is crucial for timely intervention.
Purpose of the Study:
- To determine factors predicting DGE in pediatric patients.
- To assess treatment response in children with DGE.
Main Methods:
- Retrospective analysis of 285 children (0-18 years) undergoing gastric emptying scintigraphy (GES) from 2009-2018.
- Clinical data including symptoms, medications, and history were collected.
- Multivariate regression and coefficient analysis were used, with 2-year follow-up for treatment response.
Main Results:
- 174 out of 285 children had DGE. Vomiting and reflux were the most common symptoms (>90%).
- Prior surgery, especially abdominal surgery, was a significant predictor of DGE and severe DGE.
- A notable improvement in symptoms and reduction in medication use was observed after 2 years.
Conclusions:
- This study represents a large dataset on pediatric DGE.
- Prior abdominal surgery is a critical predictor for severe DGE in children.
- Children with DGE show significant symptom and medication improvement over two years.
Objectives:
Our study attempted to identify what factors best predict for delayed gastric emptying (DGE) and whether children respond to treatment.
Methods:
Children aged between 0 and 18 were included who had a gastric emptying scintigraphy (GES) study performed between 2009 and 2018. Baseline clinical details were recorded from clinic visit records regarding symptoms, medication, and past medical history. Results were analyzed using multivariate regression analysis and coefficient analysis. Children were followed up at 2 years to assess their symptoms and medication usage.
Results:
Two hundred and eighty-five children were included in the study of which 174 demonstrated DGE. All children had symptoms prior to GES, the most common symptom being that of vomiting and reflux symptoms which were present in over 90% of patients; other common symptoms like abdominal pain and nausea were seen commonly in around 30%. A genetic disorder and prior surgery were more common in children with DGE but there was no difference in presenting symptoms between normal and DGE groups. Regression analysis showed prior surgery and particularly prior abdominal surgery predicted for DGE and additionally predicted for those with highly DGE. Improvement in symptoms and reduction in medication usage was seen after 2 years.
Conclusions:
This study provides one of the largest data sets looking at DGE in children. Prior surgery was found to be a key factor in predicting for highly DGE. Symptoms and medication usage did significantly reduce substantially after 2 years.
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