Factors Affecting Delayed Gastric Emptying and Long-Term Outcomes of Children With Gastric Emptying

Christopher Roberts1, Maryam Hussein1,2, Esme Poole1,2

  • 1From the Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.

Insights

Prior abdominal surgery is a key predictor of delayed gastric emptying (DGE) in children. Symptoms and medication needs significantly decreased two years after treatment, indicating positive patient response.

Area of Science:

  • Pediatric Gastroenterology
  • Diagnostic Imaging

Background:

  • Delayed gastric emptying (DGE) affects children, impacting their well-being.
  • Identifying predictive factors for DGE is crucial for timely intervention.

Purpose of the Study:

  • To determine factors predicting DGE in pediatric patients.
  • To assess treatment response in children with DGE.

Main Methods:

  • Retrospective analysis of 285 children (0-18 years) undergoing gastric emptying scintigraphy (GES) from 2009-2018.
  • Clinical data including symptoms, medications, and history were collected.
  • Multivariate regression and coefficient analysis were used, with 2-year follow-up for treatment response.

Main Results:

  • 174 out of 285 children had DGE. Vomiting and reflux were the most common symptoms (>90%).
  • Prior surgery, especially abdominal surgery, was a significant predictor of DGE and severe DGE.
  • A notable improvement in symptoms and reduction in medication use was observed after 2 years.

Conclusions:

  • This study represents a large dataset on pediatric DGE.
  • Prior abdominal surgery is a critical predictor for severe DGE in children.
  • Children with DGE show significant symptom and medication improvement over two years.
Abstract

Related Concept Videos

Gastric Emptying01:16

Gastric Emptying

Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
1.1K
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
243
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
257
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
133