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Decoding the genetic and epigenetic basis of asthma
Bernard S Stikker1, Rudi W Hendriks1, Ralph Stadhouders1,2
1Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Genetic and epigenetic factors significantly influence asthma susceptibility. New genomic methods link non-coding variants to asthma mechanisms, potentially transforming clinical management and risk prediction.
Area of Science:
- Pulmonary Medicine
- Genetics
- Epigenetics
Background:
- Asthma is a complex chronic airway inflammatory disease influenced by genetics and environment.
- Genome-wide association studies (GWAS) have identified numerous asthma-associated genetic variants.
- Most identified variants are in non-coding regions, hindering functional understanding.
Purpose of the Study:
- To provide an integrated overview of (epi)genetic variants associated with asthma.
- To link these variants to biological insights into asthma pathophysiology.
- To explore the potential of genetic and epigenetic discoveries in transforming asthma management.
Main Methods:
- Review of current literature on asthma genetics and epigenetics.
- Focus on state-of-the-art genomics methodologies.
- Integration of GWAS findings with epigenomic data.
Main Results:
- Advances in genomics and epigenetics enable linking non-coding variants to gene regulatory elements.
- These links are beginning to elucidate molecular mechanisms of asthma.
- Understanding the (epi)genetic basis of asthma is progressing.
Conclusions:
- Decoding the genetic and epigenetic basis of asthma is crucial for understanding its complex pathophysiology.
- This knowledge has the potential to revolutionize clinical management strategies.
- Future research can improve asthma risk prediction through genetic and epigenetic insights.
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