Related Experiment Video
Updated: Aug 12, 2025

Cell Membrane Repair Assay Using a Two-photon Laser Microscope
Published on: January 2, 2018
Role of calcium-sensor proteins in cell membrane repair
1Department of Biochemistry The University of Western Ontario, London, Ontario N6A 5C1, Canada.
Abstract:
Cell membrane repair is a critical process used to maintain cell integrity and survival from potentially lethal chemical, and mechanical membrane injury. Rapid increases in local calcium levels due to a membrane rupture have been widely accepted as a trigger for multiple membrane-resealing models that utilize exocytosis, endocytosis, patching, and shedding mechanisms. Calcium-sensor proteins, such as synaptotagmins (Syt), dysferlin, S100 proteins, and annexins, have all been identified to regulate, or participate in, multiple modes of membrane repair. Dysfunction of membrane repair from inefficiencies or genetic alterations in these proteins contributes to diseases such as muscular dystrophy (MD) and heart disease. The present review covers the role of some of the key calcium-sensor proteins and their involvement in membrane repair.
Related Concept Videos
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Enlargement of the Plasma Membrane
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Skeleton and Calcium Homeostasis
DNA Damage can Stall the Cell Cycle
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...

