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Doravirine Exposure Decreased by Dialysis in a HIV Patient: A Grand Round

Yeleen Fromage1, Cyrielle Codde2, Caroline Monchaud1,3

  • 1Department of Pharmacology, Toxicology and Pharmacovigilance, CHU de Limoges, Limoges, France.

Therapeutic Drug Monitoring
|February 2, 2023
PubMed

Insights

Hemodialysis significantly reduced doravirine concentrations by 48% in an HIV-1 patient, contrary to expectations. Therapeutic drug monitoring may be beneficial for patients on both doravirine and hemodialysis.

Area of Science:

  • Pharmacology
  • Nephrology
  • Infectious Diseases

Background:

  • A 66-year-old male patient with chronic renal failure undergoing hemodialysis was treated with doravirine and dolutegravir for HIV-1.
  • Current guidelines suggest no doravirine dose adjustment for severe renal impairment, but its interaction with dialysis is not well-established.
Abstract

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