Environment and the development of severe asthma in inner city population

Julia X Lee1, Wanda Phipatanakul2,3, Jonathan M Gaffin1,3

  • 1Division of Pulmonary Medicine, Boston Children's Hospital.

Insights

Inner-city children face severe asthma due to environmental exposures like smoke, allergens, and pollutants. Addressing these urban factors is crucial for reducing asthma burden and improving health outcomes.

Area of Science:

  • Environmental Health
  • Pediatric Respiratory Medicine
  • Urban Public Health

Background:

  • Inner-city populations, particularly low-income families in substandard housing, exhibit higher asthma prevalence and morbidity.
  • Children in these communities experience severe asthma, characterized by frequent exacerbations, emergency visits, and hospitalizations.

Approach:

  • This review synthesizes recent scientific literature on indoor and outdoor environmental exposures linked to asthma development and exacerbation.
  • The focus is on identifying key risk factors within urban settings that contribute to asthma burden.

Key Points:

  • Urban environmental exposures implicated in asthma include tobacco/e-cigarette smoke, pest allergens, molds, synthetic chemicals (phthalates, BPA), radon, and volatile organic compounds.
  • Higher levels of air pollutants and ambient heat in inner-city areas exacerbate asthma incidence and severity.
  • Substandard housing conditions are a significant factor contributing to increased childhood asthma morbidity.

Conclusions:

  • Urgent research and policy interventions are needed to mitigate the impact of urban environmental exposures on asthma.
  • Future research should focus on effective interventions and public policies to alleviate the asthma burden in urban environments.
Abstract

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
502
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.6K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.9K