Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inorganic materials to prevent liquefactive necrosis and improve wound healing: A role of infection control across ischemic models.

Materials today. Bio·2026
Same author

Tendon safety profiles of fragment-specific fixations of the distal radius extending beyond the watershed line.

The Journal of hand surgery, European volume·2026
Same author

Wide-Awake Local Anesthesia No Tourniquet (WALANT) Versus General Anesthesia for Pediatric Trigger Thumb Release: Clinical Outcomes, Efficiency, and Costs.

The Journal of hand surgery·2026
Same author

Implant removal combined with total wrist denervation for painful intra-articular distal radial malunions: a prospective study.

The Journal of hand surgery, European volume·2026
Same author

Corrigendum to "Utility of the caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty" [JPRAS Open 46 (2025) 305-315].

JPRAS open·2026
Same author

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects.

Advanced healthcare materials·2026

Related Experiment Video

Updated: Aug 12, 2025

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

2.8K

Update on Upper Limb Neuroma Management.

Anas Sayegh1, Charlotte Jaloux, Marie Witters

  • 1Department of Hand Surgery and Plastic and Reconstructive Surgery of the Limbs, La Timone University Hospital, Assistance Publique Hôpitaux de Marseille, Marseille, France.

The Journal of Craniofacial Surgery
|February 2, 2023
PubMed
Summary

New surgical techniques, including regenerative peripheral nerve interface (RPNI) and targeted muscle reinnervation (TMR), offer promising treatments for painful upper limb neuromas, potentially improving patient quality of life and prosthesis use.

More Related Videos

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

1.9K
Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers
07:59

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers

Published on: October 29, 2021

3.6K

Related Experiment Videos

Last Updated: Aug 12, 2025

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

2.8K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

1.9K
Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers
07:59

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers

Published on: October 29, 2021

3.6K

Area of Science:

  • Regenerative Medicine
  • Neurosurgery
  • Peripheral Nerve Repair

Background:

  • Painful terminal neuromas in the upper limb, resulting from nerve injury, commonly cause debilitating symptoms like sharp pain, numbness, and paresthesia.
  • These symptoms significantly impair functional ability, reduce quality of life, and can lead to abandonment of prostheses by amputees.
  • Current management of neuromas presents challenges for clinicians, necessitating advanced treatment strategies.

Purpose of the Study:

  • To provide an overview of novel surgical approaches for managing peripheral nerve neuromas.
  • To discuss the implications, surgical techniques, and outcomes of regenerative peripheral nerve interface (RPNI), targeted muscle reinnervation (TMR), and processed nerve allograft repair (PNA).

Main Methods:

  • Review of contemporary "active" surgical methods for neuroma management.
  • Detailed explanation of RPNI: inducing axonal sprouting via free nerve end transplantation into a muscle graft.
  • Description of TMR: reassigning nerve function by transferring a peripheral nerve to a nearby motor nerve.
  • Explanation of PNA: implanting a decellularized nerve matrix to facilitate nerve repair.

Main Results:

  • RPNI and TMR show promise in treating nerve-ending neuromas and preventing recurrence.
  • PNA may alleviate neuroma pain and facilitate functional nerve repair.
  • These active methods are emerging as superior alternatives to conventional "passive" techniques.

Conclusions:

  • RPNI and TMR represent significant advancements in treating upper limb neuromas, offering hope for improved functional recovery and reduced pain.
  • PNA provides a potential solution for pain reduction and meaningful nerve repair in neuroma patients.
  • These newer surgical strategies are poised to replace older, less effective methods in neuroma management.