Related Experiment Video

Updated: Aug 12, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
05:45

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

13.5K

Intussusception as Rare Presenting Sign of Pediatric Celiac Disease: A Case Series

Cory Shoshany1, Lisa M Fahey2

  • 1From Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Journal of Pediatric Gastroenterology and Nutrition
|February 2, 2023
PubMed

Insights

Intussusception in children can signal celiac disease (CD). Consider celiac screening for children over 3 with small bowel intussusception, especially if malnourished.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Disorders

Background:

  • Intussusception is a common cause of bowel obstruction in young children.
  • It typically occurs in the ileocecal region and presents with abdominal pain.
  • Recent observations suggest a link between intussusception and celiac disease (CD) in pediatric patients.

Purpose of the Study:

  • To investigate the potential association between intussusception and celiac disease in children.
  • To evaluate if intussusception could be an early indicator of pediatric celiac disease.

Main Methods:

  • Retrospective review of pediatric patients diagnosed with intussusception.
  • Analysis of patients with co-occurring biopsy-confirmed celiac disease.
  • Clinical data review, focusing on age, nutritional status, and intussusception location.

Main Results:

  • Multiple pediatric patients were diagnosed with both intussusception and celiac disease over a 5-year period.
  • Intussusception, particularly small bowel-small bowel type, occurred in children over 3 years old.
  • Malnourished patients with intussusception showed a higher incidence of celiac disease.

Conclusions:

  • Intussusception may serve as a presenting sign of pediatric celiac disease.
  • Clinical suspicion for celiac disease should be heightened in specific intussusception cases.
  • Early celiac screening is recommended for children over 3 with small bowel intussusception, especially if malnourished.

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K
Multimodality Diagnosis of Mesenteric Ischemia05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

682

Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
323
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
353
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
136
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
332
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
223
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
247